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KMID : 0921620180480020059
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Journal of Bacteriology and Virology
2018 Volume.48 No. 2 p.59 ~ p.66
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Molecular Epidemiology of Viral Conjunctivitis in the Southern Region of South Korea, 2012?2016
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Park Duck-Woong
Kim Min-Ji
Kim Kwang-Gon
Cho Sun-Ju
Park Hye-Jung
Shin Ji-Hyun
Ha Yi-Deun
Seo Mi-Hee
Kim Jang-Hoon
Lee Yeon
Park Myoung-Doo
Yoon Hi-Mo
Kim Eun-Sun
Hong Young-Jin
Kee Hye-Young
Chung Jae-Keun
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Abstract
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Epidemic keratoconjunctivitis (EKC) and acute hemorrhagic conjunctivitis (AHC) are common diseases caused by human adenoviruses (HAdV) and enteroviruses, respectively, in South Korea. However, there are limited studies on the molecular epidemiology of viral conjunctivitis in South Korea. The main objective of this study was to characterize the genotypes of adenoviruses and enteroviruses causing viral conjunctivitis in the southwest region of South Korea. We collected conjunctival swabs from 492 patients with suspected cases of viral conjunctivitis from 6 ophthalmic hospitals in Gwangju Metropolitan City, in South Korea, between 2012 and 2016. Of the 492 samples tested, HAdVs and enteroviruses were detected in 249 samples (50.6%) and 19 samples (3.9%), respectively. The genotype analysis detected HAdV-8 in 183 samples (73.5%), HAdV-37 in 14 samples (5.6%), and HAdV-3, and HAdV-4 in 9 samples (3.6%) each. We detected coxsackievirus A24 (CVA24) and coxsackievirus B1 (CVB1) in 8 samples (42.0%) and 4 samples (21.0%), respectively. We also reported for the first time HAdV-56-infected cases of EKC in South Korea. Furthermore, we found three cases of coinfection with HAdV and enterovirus genotypes in our samples. HAdV-8 and CVA24, the main causes of EKC and AHC, respectively, worldwide, were also found to be the predominant genotypes in our study.
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KEYWORD
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Viral conjuntivitis, Adenovirus, Molecular epidemiology
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